Midline defects include tongue tie, cleft lip/palate, sacral dimples/pits, neural tube defects, heart murmurs, tight anal sphincters and other congenital anomolies along the midline. They can be a sign of poor nutrition status, and seem to be associated with food sensitivities. That may be because those same nutrients are also critical for proper detox.
They are related to mom's nutritional status while pregnant, especially folate, vitamin A and her homocysteine levels.
Brian Palmer, DDS